Continuous glucose monitoring (CGM) devices provide a way to improve the quality of life for diabetes patients. As their name suggests, these devices continuously monitor blood glucose levels. This reduces the need for recurring blood tests and finger pricks. The ability to continuously monitor blood glucose without the need for drawing blood can be liberating, and will be the future of diabetes management.
Sol-Gel Production Generates Organic Byproducts
Sol-gels are a promising new way to encapsulate stable, active biomolecules. However, their production also generates organic solvents, such as methanol or ethanol, which can denature biological molecules. There are two key ways around the formation of these organic intermediates: (1) the use of new silane precursors (such as glycerated silanes or sodium silicate) or (2) the use of aqueous processing methods to quickly evaporate out organics (chemical vapor deposition).
The new silane precursors have been found to enhance both stability and function of enzymes by confining enzyme mobility. Furthermore, pH modulation during production also influences GOx activity and stability, with an optimal condensation pH of 12.
New Avenues for Glucose Oxidase Temperature Stability
Although enzymes stored on a shelf or in the lab can be quite stable, once introduced to a warm, moist, and molecularly complex in vivo environment, stability is dramatically reduced. This is a particular concern in the manufacture of implantable CGM devices. However, new promising methods to improve glucose oxidase temperature stability in an in vivo environment are on the horizon.
Whether testing new GOx immobilization methods or manufacturing CGM devices, glucose oxidase temperature stability is a notable concern for your application. By purchasing chemicals and reagents from a knowledgeable supplier, you can stay focused on what really matters – the science.
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